We offer the following regional Styrene analysis and news coverage to keep you informed of factors and developments affecting prices in the Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene The Boffetta et al. This part of the study is published in Occupational and Environmental Medicine in the article 'Sinonasal adenocarcinoma following styrene exposure in the reinforced plastics industry'. Styrene (vinyl benzene) is an economically important industrial chemical used in the synthesis and manufacture of polystyrene and hundreds of different copolymers, as well as numerous other industrial resins. Mette Skovgaard Christensen, Jesper Medom Vestergaard, Francesco d’Amore, Jette Sønderskov Gørløv, Gunnar Toft, Cecilia Høst Ramlau-Hansen, Zara Ann Stokholm, Inge Brosbøl Iversen, Mette Schou Nissen, Henrik Albert Kolstad. Teixeira et al. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. WARNING: This product contains a chemical known to the State of California to cause cancer, birth defects or other reproductive harm. Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Methods. Ultimately, more emphasis needs to be directed towards primary prevention as the most reliable channel for reducing or eliminating cancer burdens, especially among workers exposed to known carcinogens and mutagens (16,26,27). Reddit; Wechat; Abstract. Roughly 99% of the industrial resins produced from styrene can be grouped into six major categories: polystyrene (50%), styrene-butadiene rubber (15%), unsaturated polyester resins (glass reinforced) (12%), styrene-butadiene latexes (11%), acrylonitrile-butadiene-styrene (10%) and styrene-acrylonitrile (1%) (1). Styrene news and market information products from ICIS. Is that only an issue if the tv gets smashed or something? This thread is … Lung Resection For Non-Small-Cell Lung Cancer - A New Risk Score To Predict Major Perioperative Complications. The Department of Occupational Medicine at Aarhus University in Denmark has concluded that styrene may cause cancer in humans. About the United Kingdom Environmental Mutagen Society, http://ntp.niehs.nih.gov/?objectid=BD1A20B5-F1F6-975E-7CF8CBFACF0FC7EF, http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/StyreneOxide.pdf, http://www.ehjournal.net/content/10/S1/S14, Receive exclusive offers and updates from Oxford Academic, Comparison of genotoxic potency of styrene 7,8-oxide with γ radiation and human cancer risk estimation of styrene using the rad-equivalence approach, Styrene monomer does not induce unscheduled DNA synthesis in the mouse liver following inhalation exposure. He is professor in occupational medicine, at the Department of Clinical Medicine at Aarhus University as well as Aarhus University Hospital. The latter cover cause-effect studies based on biological material. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. Reddit; Founded in 1976 ... the singer has revealed she’s battling breast cancer. "After 40 years in limbo: Styrene is probably carcinogenic." (styrene and [cancer or neoplasms] and [epidemiology or mortality or in-cidence]), without restriction of lan-guage or date of publication, as well as the references in the recent IARC Monograph1 and NTP Background Document.8 In a second PubMed search, we used the terms ([lymphoma or Hodgkin or Hodgkin’s or leukemia or … The European Union undertook a risk assessment of styrene and concluded that, “based on human studies, there is no clear and consistent evidence for a causal link between specific cancer mortality and exposure to styrene” (EU 2008, p. 271). In some studies, the risks increased with increasing measures of exposure, such as average exposure, cumulative exposure, or number of years since first exposure. Materials provided by Aarhus University. and their health effects. Styrene is … Styrene is upgraded from possibly carcinogenic to probably carcinogenic for humans, and the decision is largely based on register-based studies from Aarhus together with new animal evidence. Although some studies suggest that styrene-exposed workers may be at increased cancer risk, the human evidence for styrene carcinogenicity is inconclusive. In California this led to requirements for special product labelling, while EU countries do not have to label Roundup as a carcinogen. 100-42-5. CAS No. Philadelphia-negative myeloproliferative neoplasms among Kuwaiti Nationals. P.F.I. Sciences study of Styrene and cancer. Le styrène ne figurant pas sur la liste européenne des produits cancérogènes, il n’y a pas d’obligation d’appliquer le décret 2001-97 du 1er février 2001, dit décret CMR. Content on this website is for information only. 96-09-3. Causality is not established, as the possibility that the results were due to chance or to confounding by exposure to other carcinogenic chemicals cannot be completely ruled out. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. ScienceDaily shares links with sites in the. There is also some evidence for increased risks of esophageal and pancreatic cancer among styrene-exposed workers. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. The Factors That Do Increase Cancer Risk. Hence, based on both animal and human cancer studies and genotoxic findings including clastogenicity and DNA damage in workers as well as on other supportive and biologically plausible mechanistic results, styrene and styrene-7,8-oxide should be considered as presenting carcinogenic risks to humans, particularly for lymphatic/hematopoietic cancers. Human Studies: The limited evidence for cancer from styrene in humans is from occupational studies showing increased risks for lymphohematopoietic cancers, such as leukemia and lymphoma, and genetic damage in the white blood cells, or lymphocytes, of workers exposed to styrene. Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. But now an impartial working group under the auspices of WHO and appointed by the International Agency for Research on Cancer (IARC), has upgraded the warning. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … Aarhus University. (2) recently reported cytogenetic and DNA damage in workers exposed to styrene and concluded their findings were supported by previous study results demonstrating genotoxicity associated with occupational exposure to styrene (e.g. ScienceDaily. Oxford University Press is a department of the University of Oxford. Does styrene cause cancer? Some scientists think it’s already over. Enough already The styrene toxicity database available today provides ample support for a conclusion of “no concern” for styrene and cancer. We've requested the relevant data in anonymised form from the companies that analyse the measurements , but unfortunately, we were unable to gain access to them," says Henrik Kolstad, "This is deeply regrettable, because the fact is that good answers to important questions presupposes that we also have access to the relevant information in the future.". Styrene news and market information products from ICIS. ScienceDaily, 30 May 2018. The move came in response to the results of a comprehensive study carried out by researchers from Aarhus University, along with new animal … Reasonably Anticipated to Be a Human Carcinogen. The reason for different classifications from different organizations is partly a … Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. Styrene has been classified by the International Agency for Research on Cancer (IARC) as Group 2A, probably carcinogenic to humans, based on limited human and sufficient animal evidence. What about other health effects? Copyright © 2020 Oxford University Press and United Kingdom Environmental Mutagen Society. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. One example is the monograph, which recently showed that diesel exhaust can cause lung cancer. . Henrik Kolstad emphasizes that the Danish register findings reflect the sins of the past. For permissions, please e-mail: journals.permissions@oup.com. Many companies take measurements, but they are not publicly available. Search for other works by this author on: Styrene. 3). Issues, controversies, and uncertainties. Questions? The study has involved a comprehensive linkage of registers, where the researchers used the central business register , along with various other company registers, to identify the relevant companies and their employees. Styrene is an industrial chemical used to produce a number of different … wind turbines or yachts. Manufactured styrene may contain aldehydes, which give it a sharp, unpleasant odor. Elevated risks of lymphohematopoietic cancer were found among workers with higher exposure to styrene after an appropriate elapsed time since first exposure. Title: Styrene Cancer Warning Upheld. But in a time when new studies on cancer links make news weekly, it’s easy to lose sight of the clear and consistent evidence: many common cancers have their roots in lifestyle factors. Styrene officially linked to cancer . The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. Among others before, Teixeira et al. However, the types of lymphohematopoietic cancer observed in excess varied across different cohort studies, and excess risks were not found in all cohorts. Out of the more than 70,000 people included in the research project, we found 25 cases of acute myeloid leukaemia, where you would statistically expect to find 10," says Professor Henrik Kolstad with reference to the research article 'Styrene exposure and risk of lymphohematopoietic malignancies in 73,036 reinforced plastics workers', published in Epidemiology. En matière de prévention, il demeure important de savoir que le styrène est considéré comme «peut-être cancérogène pour l’homme» selon le Centre international de recherche contre le cancer. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’ The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers… After this stage, the information was linked with the Danish Cancer Register to assess the incidence of different types of cancer among the employees compared to the general population's risk of developing the same diseases. save. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’. Additionally, increases in cancer ‘at these sites were also observed in some of the individual cohort studies, and there was some evidence of an exposure–response relationship with pancreatic cancer’ (1). EcoWatch, July 29, 2014 July 30, 2014. It is important … This fact sheet is one in a series of summaries about hazardous substances . (6) styrene review paper ‘that no consistent increased risk of any cancer among workers exposed to styrene was found. "Clearly, the best place to study the possible health effects of styrene exposure is in the reinforced plasticsindustry, where no butadiene is involved. Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. Four styrene laden products to ditch Planning a summer barbecue this weekend or stocking up for Labor Day? There is also some evidence for increased risk of cancer in the pancreas or esophagus among some styrene … Moreover, in the interests of public and occupational health, we suggest that authors be more cautious in their casual acceptance of industry papers and reviews of epidemiological study results related to occupational exposure to styrene (or other chemicals). Le formaldéhyde, substance présente notamment dans les matières plastiques, et le styrène font désormais partie de la liste des produits cancérigènes. The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. Exposure to styrene may increase the risk of cancer. The critical impact of tumor size in predicting cancer special survival for T3aM0M0 renal cell carcinoma: A proposal of an alternative T3aN0M0 stage. © The Author 2011. Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. Styrene is included in synthetic rubber, some insulation materials, disposable tableware, packaging and fiberglass plastic. Or view hourly updated newsfeeds in your RSS reader: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Styrene is a colorless liquid that evaporates easily. 12th Report on Carcinogens, National Toxicology Program, Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, Epidemiologic studies of styrene and cancer: a review of the literature, RE: Request for NTP to Fully Consider New Styrene Epidemiology Review Prior to Finalizing Styrene Draft Substance Profile, 16 Dec 2008, 3 page letter to Wilson SH, NIEHS from Synder J, SIRC. Do RNA vaccines obviate the need for genotoxicity studies? 16 . Both are genotoxic and form DNA adducts in humans. Aarhus University. Benchmark dose analysis of multiple genotoxicity endpoints in, Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients, The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals, Detection of urethane-induced genotoxicity. Government Agency reviews also concluded that styrene and its major metabolite styrene-7,8-oxide (SO) are both mutagenic and clastogenic as well as carcinogenic (1,4). Other countries have done nothing. review (6,7). California Health & Safety Code Section 25249.6. Such frustration is understandable. "We've tried to make it clear that a listing in the report doesn't necessarily mean that encountering that substance in any minute quantity means you'll get cancer," said NTP Associate Director John Bucher. Conflict of interest statement: None declared. 100% Upvoted. In 2011, styrene, a high volume plastics chemical and animal carcinogen, was the focal point in a ‘poison scandal’ in the Danish media; but now a registry study of more than 72,000 employees from more than 400 companies that have been exposed to styrene during production of glassfibre reinforced plastics, has not found an increased incidence of a wide range of cancer … http://ntp.niehs.nih.gov/files/20081216SIRC.pdf (accessed June 20, 2011), Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study, Cancer incidence among petrochemical workers in the Porto Torres industrial area, 1990–2006, Cancer incidence among petrochemical workers in the Porto Torres industrial area, Styrene, styrene oxide, polystyrene, and beta-nitrostyrene/styrene carcinogenicity in rodents, Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals, Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall, Predicting chemicals causing cancer in animals as human carcinogens, Alleged misconceptions' distort perceptions of environmental cancer risks, Role of experimental and epidemiological evidence of carcinogenicity in the primary prevention of cancer, Identification of carcinogenic agents and primary prevention of cancer, Prevention versus chemophobia: a defence of rodent carcinogenicity tests, Long-term chemical carcinogenesis bioassays predict human cancer hazards. share. (6) review on behalf of Styrene Information and Research Center, a styrene industry organisation, was presented by co-author P. Cole to the National Toxicology Program’s (NTP) Board of Scientific Counsellors open-to-the-public Peer Review of styrene (7). 0.75 0.01 0.76 Forced … However, it was not possible to establish whether the American workers contracted leukaemia from handling styrene or from butadiene, a chemical, which is styrene's permanent companion in the production of synthetic rubber -- and this is where the Danish register-based studies come into the picture. Styrene is the precursor … The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers, genotoxicity and mechanism is further bolstered by the 2010 case–control study in six European countries by Cocco et al. The new announcement from the World Health Organisation will be published by IARC as a Monograph, authored by 23 handpicked researchers from around the world, including Professor Henrik Kolstad. Butadiene or styrene or butadiene and styrene or else? report. 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